ESR Project 7
Florine Jiwa is a PhD candidate at the Amsterdam University Medical Center in Amsterdam.
Before starting her PhD she obtained a Bsc in Nutrition and Dietics in 2015 and graduated as a medical doctor at the Vrije Universiteit (Amsterdam) in 2021.
Her project focuses on identifying metabolic and microbial features to explain the success of fecal microbiota transplantation in inflammatory bowel disease, specifically ulcerative colitis. The goal of this project is to identify bacterial signatures associated with sustained remission of ulcerative colitis. For this she will work closely with an ongoing clinical trial, the TURN2 trial, which investigates anaerobically processed fecal microbiota transplantation in patients with ulcerative colitis. To study the interactions of identified bacterial enterotypes and metabotypes associated with remission she will use a metabolomics approach, performed at Imperial College London, UK, and gut-on-a-chip models at the Technology institute (TNO), Netherlands. Finally, primary cell derived organoid models will be used to model cellular and molecular effects of identified metabolites or signalling molecules on epithelial cell proliferation and differentiation.
Host Institution: Imperial College London & Amsterdam University Medical Center
Main supervisor: Prof. dr. C.Y. Ponsioen & Prof. dr. W. de Jonge
Co-supervisor: Prof. dr. J. Kinross